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Glucovanceglyburide/metforminis a combination antidiabetic medication containing glyburide and metforminGlucovance is used to improve blood glucosesugarcontrol in adults with type 2 diabetes mellitusGlyburide is a second-generation oral sulfonylureaIt helps to lower blood glucose by stimulating the release of insulinthe hormone responsible for regulating blood glucoseIn clinical studiesglyburide/metformin therapy was observed to be superior in improving fasting plasma glucosepost-meal blood glucoseand HbA1c levels versus treatment with glyburide or metformin alone.

Topiramate or other carbonic anhydrase inhibitorse.gzonisamideacetazolamide or dichlorphenamidefrequently causes a decrease in serum bicarbonate and induce non-anion gaphyperchloremic metabolic acidosisConcomitant use of these drugs with Glucovance may increase the risk for lactic acidosisConsider more frequent monitoring of these patients.

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