agosto 24, 2018 | Posted in:Blog

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If any of the following conditions are presenthave occurred previouslyand/or have been aggravated during pregnancy or previous hormone treatmentthe patient should be closely supervisedIt should be taken into account that these conditions may recur or be aggravated during treatment with Premarinin particular:

In postmenopausal womenestrogens can increase the risk of cancer of the ovariesstrokedementiaand serious blood clots in the legsEstrogens alone do not appear to increase the risk of breast cancer when used for up to 7 yearsEstrogenwhen used with a progestincan increase the risk of heart diseasesuch as heart attacksstrokeserious blood clots in the lungs/legsdementiaand cancer of the breast/ovaries.

No drug interaction studies have been conducted for PREMARIN Vaginal Cream.

In the WHI estrogen-alone substudya statistically significant increased risk of stroke was reported in women 50 to 79 years of age receiving daily CE0.625 mgalone compared to women in the same age group receiving placebo45 versus 33 per 10,000 women-yearsThe increase in risk was demonstrated in year 1 and persistedsee Clinical StudiesShould a stroke occur or be suspectedestrogen-alone therapy should be discontinued immediately.

There arehoweverpossible risks that may be associated with the use of progestins with estrogens compared to estrogen-alone regimensThese include an increased risk of breast cancer.

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