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Tell your doctor about all your current medicinesMany drugs can affect esomeprazoleespecially:

Some conditions are treated with a combination of esomeprazole and antibioticsUse all medications as directed.

Teratogenicity was not observed in animal reproduction studies with administration of oral esomeprazole magnesium in rats and rabbits with doses about 68 times and 42 timesrespectivelyan oral human dose of 40 mgbased on a body surface area basis for a 60 kg personHoweverchanges in bone morphology were observed in offspring of rats dosed through most of pregnancy and lactation at doses equal to or greater than approximately 34 times an oral human dose of 40 mgsee Animal DataBecause of the observed effect at high doses of esomeprazole magnesium on developing bone in rat studiesNEXIUM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

The symptoms described in connection with deliberate NEXIUM overdoselimited experience of doses in excess of 240 mg/dayare transientSingle doses of 80 mg of esomeprazole were uneventfulReports of overdosage with omeprazole in humans may also be relevantDoses ranged up to 2,400 mg120 times the usual recommended clinical doseManifestations were variablebut included confusiondrowsinessblurred visiontachycardianauseadiaphoresisflushingheadachedry mouthand other adverse reactions similar to those seen in normal clinical experiencesee omeprazole package insertAdverse ReactionsNo specific antidote for esomeprazole is knownSince esomeprazole is extensively protein boundit is not expected to be removed by dialysisIn the event of overdosagetreatment should be symptomatic and supportive.

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store nexium at room temperature, between 68 and 77 degrees f 20 and 25 degrees c .

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