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Common side effects of Casodex includeabdominal painnauseaand mastalgiaOther side effects includeflu-like symptomsgynecomastiavomitingand anorexiaSee below for a comprehensive list of adverse effects.

Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Casodex 150 mg daily is not approved for use in patients with locally advancedT3-4NXM0cancer of the prostateFollowing discontinuation of all M1 patientsthe trials continued with the T3-4NXM0 patients until study completionIn the larger trialN=352the risk of death was 25HR 1.2595CI 0.92 to 1.71higher in the Casodex group and in the smaller trialN=140the risk of death was 36HR 0.6495CI0.39 to 1.03lower in the Casodex group.

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