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Concurrent QT-prolonging drugs that are metabolized via the enzyme CYP3A4 (cisapride.erythromycin.pimozide.and quinidine)

Pimozide . Although not studied in vitro or in vivo .concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism. Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsades de pointes . Coadministration of fluconazole and pimozide is contraindicated (see section 4.3).

Prothrombin time may be increased in patients receiving concomitant DIFLUCAN and coumarin-diflucan back order anticoagulants. In post-marketing experience.as with other azole antifungals.bleeding events (bruising.epistaxis.gastrointestinal bleeding.hematuria.and melena) have been reported in association with increases in prothrombin time in patients receiving fluconazole concurrently with warfarin. Careful monitoring of prothrombin time in patients receiving DIFLUCAN and coumarin-type anticoagulants is recommended. Dose adjustment of warfarin may be necessary. (See CLINICAL PHARMACOLOGY . Drug Interactions Studies .)

Halofantrine has been shown to prolong QTc interval at the recommended therapeutic dose and is a substrate of CYP3A4. The concomitant use of fluconazole and halofantrine is therefore not recommended (see section 4.5).

Prepare a suspension at time of dispensing as follows. tap bottle until diflucan back order the powder flows freely. To reconstitute.add 24 mL of distilled water or Purified Water (USP) to fluconazole bottle and shake vigorously to suspend powder. Each bottle will deliver 35 mL of suspension. The concentrations of the reconstituted suspensions are as follows.

Fluconazole is a potent CYP2C9 inhibitor and a moderate CYP3A4 inhibitor. Fluconazole treated patients who are concomitantly treated with drugs with a narrow therapeutic window metabolized through CYP2C9 and CYP3A4 should be monitored.

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Capsules contain lactose monohydratePatients with rare hereditary problems of galactose intolerancethe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

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Fluconazole passes into breast milk but is unlikely to harm a nursing infantConsult your doctor before breast-feeding.

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Non-steroidal anti-inflammatory drugsThe C max and AUC of flurbiprofen was increased by 23and 81respectivelywhen coadministered with fluconazole compared to administration of flurbiprofen aloneSimilarlythe C max and AUC of the pharmacologically active isomerSibuprofenwas increased by 15and 82respectivelywhen fluconazole was coadministered with racemic ibuprofen400 mgcompared to administration of racemic ibuprofen alone.

BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

Vitamin ABased on a case-report in one patient receiving combination therapy with all-trans-retinoid acidan acid form of vitamin Aand fluconazoleCNS related undesirable effects have developed in the form of pseudotumour cerebriwhich disappeared after discontinuation of fluconazole treatmentThis combination may be used but the incidence of CNS related undesirable effects should be borne in mind.

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Ketoconazole is known to cause adrenal insufficiencyand this could also although rarely seen be applicable to fluconazoleAdrenal insufficiency relating to concomitant treatment with prednisonesee section 4.5The effect of fluconazole on other medicinal products

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