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After initiation of duetact, patients should be carefully monitored for adverse events related to fluid retention see boxed warning and warnings, pioglitazone hydrochloride .

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Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Pioglitazone hydrochloride was not mutagenic in a battery of genetic toxicology studies.including the Ames bacterial assay.buy duetact coupon mammalian cell forward gene mutation assay (CHO/HPRT and AS52/XPRT).an in vitro cytogenetics assay using CHL cells.an unscheduled DNA synthesis assay.and an in vivo micronucleus assay.

Pioglitazone may increase your risk of serious heart problems. However.not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking Duetact.

severe or advanced heart failure. active bladder cancer. or diabetic ketoacidosis (call your doctor for treatment).

In postmarketing experience.there have buy duetact coupon reports of unusually rapid increases in weight and increases in excess of that generally observed in clinical trials. Patients who experience such increases should be assessed for fluid accumulation and volume-related events such as excessive edema and congestive heart failure [see BOX WARNING and WARNINGS AND PRECAUTIONS ].

There were no differences between males and females in the pharmacokinetics of glimepiride buy duetact coupon adjustment was made for differences in body weight.

When colesevelam is coadministered with glimepiride.maximum plasma concentration and total exposure to glimepiride is reduced. Therefore.DUETACT should be administered at least four hours prior to colesevelam see DRUG INTERACTIONS and CLINICAL PHARMACOLOGY ].

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Before taking this medicationtell your doctor or pharmacist if you are allergic to pioglitazone or glimepirideor to otherglitazonese.grosiglitazoneor to other sulfonylurease.gglipizidetolbutamideor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drinkBe sure your family and close friends know how to give you this injection in an emergency.

This medicine may increase the risk for bone fractures in womenAsk your doctor about ways to keep your bones strong to help prevent fractures.

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicinesAlso tell your health care professional if you have any other types of allergiessuch as to foodsdyespreservativesor animalsFor non-prescription productsread the label or package ingredients carefully.

This medicine can cause hypoglycemialow blood sugarLow blood sugar can also occur if you delay or miss a meal or snackexercise more than usualdrink alcoholor cannot eat because of nausea or vomitingLow blood sugar must be treated before it causes you to pass outunconsciousnessPeople feel different symptoms with low blood sugarIt is important that you learn which symptoms of low blood sugar you have in order to treat it quicklyTalk to your doctor about the best way to treat low blood sugar.

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CommentsTake with first meal of the dayFor patients switching from a different sulfonylureacarefully monitor for hypoglycemia for 1 to 2 weeks due to a potential overlapping drug effectIf hypoglycemia occurs in a patient coadministered an insulin secretagoguethe dose of the insulin secretagogue should be reducedIf hypoglycemia occurs in a patient’s coadministered insulinthe insulin dose should be decreased by 10to 25with further adjustments based on glycemic response.

Pioglitazone belongs to a class of drugs known as thiazolidinediones orglitazonesIt works by helping to restore your body’s proper response to insulinthereby lowering your blood sugar.

Indicated for type 2 diabetes mellitus in patients treated with combination of pioglitazone and a sulfonylureaor patients not adequately controlled on a sulfonylurea aloneor who have initially responded to pioglitazone and require additional glycemic control Management of diabetes mellitus as adjunct to diet and exercise.

The dose of this medicine will be different for different patientsFollow your doctor’s orders or the directions on the labelThe following information includes only the average doses of this medicineIf your dose is differentdo not change it unless your doctor tells you to do so.

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The amount of medicine that you take depends on the strength of the medicineAlsothe number of doses you take each daythe time allowed between dosesand the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Duetact is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Symptomatic HFnot recommendedMonitor for signs/symptoms of CHFdiscontinue or reduce dose if occursEdemaGlimepiridepotential increased risk of cardiovascular mortalityHepatic diseaseMonitor liver function before initiating therapyif abnormalities detectedinterrupt and assess probable causedo not restart if ALT3XULN with total bilirubin2XULNRoutine monitoring LFTs during therapy without liver diseasenot recommendedActive bladder cancernot recommendedPrior history of bladder cancerconsider glycemic control benefits vs risk of cancer recurrenceRisk of fracturesespfemalesStressElderlydebilitateduncompensated strenuous excercisemalnourished or deficient caloric intakeadrenal or pituitary insufficiencyor alcohol intoxicationincreased risk of hypoglycemiaG6PD deficiencyconsider non-sulfonylurea alternativeRenal impairmentPerform regular eye examsResumption of premenopausal ovulation in anovulatory women may occurmay result in unintended pregnancyPregnancyNursing mothers.

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