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Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nausea.vomiting.salivation.sweating.bradycardia.hypotension.respiratory depression.collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Atypical responses in blood pressure and heart rate have been reported with other drugs that increase cholinergic activity when coadministered with quaternary anticholinergics such as glycopyrrolate. Additional symptoms associated with rivastigmine overdose are diarrhea.abdominal pain.dizziness.tremor.headache.somnolence.confusional state.hyperhidrosis.hypertension.hallucinations and malaise. Due to the short half-life of rivastigmine.dialysis (hemodialysis.peritoneal dialysis.or share price exelon) would not be clinically indicated in the event of an overdose.

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Rivastigmine.as a share price exelon inhibitor.is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.

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EXELON can cause gastrointestinal adverse reactionsincluding significant nauseavomitingdiarrheaanorexia/decreased appetiteand weight lossDehydration may result from prolonged vomiting or diarrhea and can be associated with serious outcomesThe incidence and severity of these reactions are dose-relatedsee ADVERSE REACTIONSFor this reasonpatients should always be started at a dose of 1.5 mg twice a day and titrated to their maintenance dose.

Known hypersensitivity to rivastigmineother carbamate derivatives or other components of the formulationsee DESCRIPTIONa previous history of application site reaction with rivastigmine transdermal patch suggestive of allergic contact dermatitisin the absence of negative allergy testingsee WARNINGS AND PRECAUTIONS

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Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

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The rate of discontinuation due to adverse events in the single placebo-controlled trial of EXELON was 18for patients receiving 3 mg to 12 mg per day compared to 11for patients on placebo during the 24-week study.

Rivastigmine shows linear pharmacokinetics up to 3 mg twice a day but is nonlinear at higher dosesDoubling the dose from 3 mg to 6 mg twice a day results in a 3-fold increase in AUCThe elimination half-life is about 1.5 hourswith most elimination as metabolites via the urine.

EXELON has been administered to over 5,297 individuals during clinical trials worldwideOf these4,326 patients have been treated for at least 3 months3,407 patients have been treated for at least 6 months2,150 patients have been treated for 1 year1,250 patients have been treated for 2 yearsand 168 patients have been treated for over 3 yearsWith regard to exposure to the highest dose2,809 patients were exposed to doses of 10 mg to 12 mg2,615 patients treated for 3 months2,328 patients treated for 6 months1,378 patients treated for 1 year917 patients treated for 2 yearsand 129 patients treated for over 3 years.

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In overdoses accompanied by severe nausea and vomitingthe use of antiemetics should be consideredA fatal outcome has been rarely reported with rivastigmine

In a second study of 26 weeks duration725 patients were randomized to either a dose range of 1 mg to 4 mg or 6 mg to 12 mg of EXELON per day or to placeboeach given in divided dosesThe 26-week study was divided into a 12-week forced-dose titration phase and a 14-week maintenance phaseThe patients in the active treatment arms of the study were maintained at their highest tolerated dose within the respective range.

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On the plus sideExelon is the largest diversified utility with multiple revenue streamsThey are relatively cheap and pay a decent dividendBut that comes with a costthey are heavily invested in nuclear power generationwhich comes with a potentially explosive downside costIn additionthey are slightly more debt dependent that the average utility over the last few yearsIf you’re interested in this issueunderstand these two risks before investing.

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