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Keppra injection is for intravenous use only as an alternative for patients when oral administration is temporarily not feasible.Brain Disorders Image Collection.

KEPPRA can cause anaphylaxis or angioedema after the first dose or at any time during treatment. Signs and symptoms in cases reported in the postmarketing setting have included hypotension.hives.rash.respiratory distress.and swelling of the face.lip.mouth.eye.tongue.throat.and feet. In some reported cases.reactions were lifethreatening and required emergency treatment. If a patient develops signs or symptoms of anaphylaxis or angioedema.KEPPRA should be discontinued and the patient should seek immediate medical attention. KEPPRA should be discontinued permanently if a clear alternative etiology for the reaction cannot be established [see CONTRAINDICATIONS ].

There was about a 22% increase of apparent total body clearance of levetiracetam when it was co-administered with enzyme-inducing AEDs. Dose adjustment is not recommended. Levetiracetam had no effect on plasma concentrations of carbamazepine.valproate.topiramate.or lamotrigine.

Keppra (levetiracetam) is an anti-epileptic drug.also called an anticonvulsant.

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Potential pharmacokinetic interactions of or with levetiracetam were assessed in clinical pharmacokinetic studies (phenytoin.valproate.warfarin.digoxin.oral contraceptive.probenecid) and through pharmacokinetic screening in the placebo-controlled clinical studies in epilepsy patients.

Some people have thoughts about suicide when first taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

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The population included 164 patients keppra n 80, placebo n 84 with idiopathic generalized epilepsy predominately juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, or epilepsy with grand mal seizures on awakening experiencing primary generalized tonic-clonic seizures.

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Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetamThereforemacrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.

No impact on fertility was detected in animal studiessee section 5.3No clinical data are availablepotential risk for human is unknown.

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Adjunctive therapy in the treatment of partial onset seizures in adults and children 1 month of age and older with epilepsyadjunctive therapy in the treatment of myoclonic seizures in adults and adolescents 12 years of age and older with Juvenile Myoclonic EpilepsyJMEadjunctive therapy in the treatment of Primary Generalised Tonic-ClonicPGTCseizures in adults and children 6 years of age and older with Idiopathic Generalised EpilepsyIGE

In all of these studiesthe main measure of effectiveness was the change in the number of seizures before and during treatment.

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Keppra used on its own has been studied in 579 patients with partial-onset seizures aged 16 years and overwho received either Keppra or carbamazepineanother anti-epileptic medicinefor up to two yearsThe study measured how many patients remained free of seizures for six months once they had reached their effective dose.

In clinical studies13of adult KEPPRA-treated patients and 38of pediatric KEPPRA-treated patients4 to 16 years of agecompared to 6and 19of adult and pediatric placebo-treated patientsexperienced non-psychotic behavioral symptomsreported as aggressionagitationangeranxietyapathydepersonalizationdepressionemotional labilityhostilityhyperkinesiasirritabilitynervousnessneurosisand personality disorder

The overall adverse reaction profile of KEPPRA was similar between females and malesThere are insufficient data to support a statement regarding the distribution of adverse reactions by age and race.

The highest known dose of KEPPRA received in the clinical development program was 6000 mg/dayOther than drowsinessthere were no adverse reactions in the few known cases of overdose in clinical trialsCases of somnolenceagitationaggressiondepressed level of consciousnessrespiratory depression and coma were observed with KEPPRA overdoses in postmarketing use.

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