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Mestinonpyridostigmine bromide tabletsUSPis an orally active cholinesterase inhibitorChemicallypyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamateIts structural formula is:

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8Breyer-Pfaff UMaier UBrinkmann AMSchumm FPyridostigmine kinetics in healthy subjects and patients with myasthenia gravisClin Pharmacol Ther1985;5:495-501.

Timespan Tablets are available as light straw-coloredcapsule-shaped tablets containing 180 mg pyridostigmine bromide in bottles of 30NDC 0187-3013-30Each tablet is engravedMES V 180on one side and is single-scored on the other.

One to three 180 mg tabletsonce or twice dailywill usually be sufficient to control symptomshoweverthe needs of certain individuals may vary markedly from this averageThe interval between doses should be at least 6 hoursFor optimum controlit may be necessary to use the more rapidly acting regular tablets or syrup in conjunction with Timespan therapy.

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1Osserman KEGenkins GStudies in myasthenia gravisReduction in mortality rate after crisisJAMAJan 1963183:97-101.

Side effects include drowsinessnauseadiarrheaand pain in the abdomen.

NOTEFor information on a diagnostic test for myasthenia gravisand for the evaluation and stabilization of therapyplease see product literature on Tensilonedrophonium chloride

6Cronnelly RStanski DRMiller RDSheiner LBPyridostigmine kinetics with and without renal functionClin Pharmacol Ther198028:No178-81.

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