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Ahelp restore normal serum potassium levels in patients who develop hypokalemia on the kaliuretic diuretic.

Causal Relationship UnknownOther reactions have been reported but occurred under circumstances where a causal relationship could not be establishedHoweverin these rarely reported eventsthat possibility cannot be excludedThereforethese observations are listed to serve as alerting information to physicians.

Midamor can raise the levels of potassium in your bloodYou will need frequent blood tests while taking Midamor.

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Antikaliuretic therapy should be instituted only with caution in severely ill patients in whom respiratory or metabolic acidosis may occursuch as patients with cardiopulmonary disease or poorly controlled diabetesIf MIDAMORamilorideis given to these patientsfrequent monitoring of acid-base balance is necessaryShifts in acid-base balance alter the ratio of extracellular/intracellular potassiumand the development of acidosis may be associated with rapid increases in serum potassium levels.

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Midamor is a potassium-sparing diureticIt works by making the kidneys eliminate sodiumsaltand water from the body while retaining potassium.

MIDAMORamilorideshould not be used in the presence of elevated serum potassium levelsgreater than 5.5 mEq per liter

Amiloride HCI is not metabolized by the liver but is excreted unchanged by the kidneysAbout 50 percent of a 20 mg dose of MIDAMORamilorideis excreted in the urine and 40 percent in the stool within 72 hoursMIDAMORamiloridehas little effect on glomerular filtration rate or renal blood flowBecause amiloride HCl is not metabolized by the liverdrug accumulation is not anticipated in patients with hepatic dysfunctionbut accumulation can occur if the hepatorenal syndrome develops.

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