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Treatment of renal disease in hypertensive patients with Type 2 diabetes mellitus and incipient nephropathysee section 5.1
You must tell your doctor if you think you areor might becomepregnantYour doctor will normally advise you to stop taking Zestril before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of ZestrilZestril is not recommended in early pregnancyand must not be taken when more than 3 months pregnantas it may cause serious harm to your baby if used after the third month of pregnancy.
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In clinical studiesthere was no age-related change in the efficacy or safety profile of the drugWhen advanced age is associated with decrease in renal functionhoweverthe guidelines set out in Table 1 should be used to determine the starting dose of ZestrilThereafterthe dosage should be adjusted according to the blood pressure response.
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The recommended initial dose is 2.5 mg once daily in patients 20 to 6 years oldbut no experience in other indicationssee section 5.1Zestril is not recommended in children in other indications than hypertension.
Following oral administration of lisinoprilpeak serum concentrations occur within about 7 hoursalthough there was a trend to a small delay in time taken to reach peak serum concentrations in acute myocardial infarction patientsBased on urinary recoverythe mean extent of absorption of lisinopril is approximately 25with interpatient variability of 6-60over the dose range studied5-80 mgThe absolute bioavailability is reduced approximately 16in patients with heart failureLisinopril absorption is not affected by the presence of food.
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Each tablet contains lisinopril dihydrate equivalent to 5 mg10 mgor 20 mg anhydrous lisinopril.
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