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High cholesterol and triglyceride levels increase the risk of cardiovascular disease. Getting your cholesterol and triglyceride.

Coadministration with a statin in the presence of active liver disease or persistent.unexplained elevations of hepatic transaminase levels.

Concomitant cholestyramine administration decreased the mean area under the curve (AUC) of total ezetimibe approximately 55%. The incremental LDL-C reduction due to adding ezetimibe to cholestyramine may be reduced by this interaction.

The effect of ZETIA on cardiovascular morbidity and mortality has not been determined.

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Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

This drug may increase the risk of liver damagewhen taken with astatinor muscle damage when taken with a fibrate orstatinTell your doctor right away if you experience any of the following symptomssigns of liver problemssuch as severe stomach/abdominal painpersistent nausea/vomitingyellowing eyes/skindark urinemuscle pain/tenderness/weaknessespecially with fever or unusual tiredness

ZETIAadded to on-going statin therapysignificantly lowered total-CLDL-CApo Bnon-HDL-Cand TGand increased HDL-C compared with a statin administered alonesee Table 7LDL-C reductions induced by ZETIA were generally consistent across all statins.

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For High CholesterolAfter having difficulties with Simvastatinsudden flailing of limbsLovazahyperhydrosisTricorworse hyperhydrosisfatigueacid refluxand high dose Niacinsame but worseI was put on Zetiahyperhydrosis to the point of hyponatremiaconstant sweating even in 30F weatherlow sodiuminability to walkbreathe for more than a few steps at a timereduced cardiacrespiratory functionclammy skinconstant feeling of being on firenormal body temp but FELT like I was burning alivefatigueandsevere craving for milkI was drinking 2 to 2 1/2 GALLONS of milk PER DAYI was always dehydratedI gained 50 lbs on skim milkDid lower my triglycerides but almost killed meImproved swiftly after stopping Zetia

Patients have experienced severe muscle problems while taking ZETIAusually when ZETIA was added to a statin drugIf you experience unexplained muscle paintendernessor weakness while taking ZETIAcontact your doctor immediatelyYou need to do this promptlybecause on rare occasionsthese muscle problems can be seriouswith muscle breakdown resulting in kidney damage.

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It is not known whether Zetia alone will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnantUse effective birth control to prevent pregnancy while you are using ezetimibe with a statin medication.

Concomitant cholestyramine administration decreased the mean area under the curveAUCof total ezetimibe approximately 55The incremental LDL-C reduction due to adding ezetimibe to cholestyramine may be reduced by this interaction.

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