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Do not use this medicine if you have used an MAO inhibitor in the past 14 days.such as isocarboxazid.linezolid.methylene blue injection.phenelzine.rasagiline.selegiline.or tranylcypromine.
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Pharmacokinetic information generated in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) linezolid concentrations following single and multiple dosing of linezolid. therapeutic concentrations were not consistently achieved or maintained in the CSF. Therefore.the use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended.
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Do not use linezolid if you have taken an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidmethylene blue injectionphenelzinerasagilineselegilineand tranylcypromine.
Linezolid is not active against infections caused by Gram negative pathogensLinezolid should only be used in patients with complicated skin and soft tissue infections with known or possible co-infection with Gram negative organisms if there are no alternative treatment options availablesee section 4.4In these circumstances treatment against Gram negative organisms must be initiated concomitantly.
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This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicityThe risk increases if you are also taking other drugs that increase serotoninso tell your doctor or pharmacist of all the drugs you takeGet medical help right away if you develop some of the following symptomsfast heartbeathallucinationsloss of coordinationsevere dizzinessunexplained feversevere nausea/vomiting/diarrheatwitching musclesunusual agitation/restlessness.
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Binds to bacterial 23S rRNA of the 50S subunit to prevent protein translationalso elicits nonselective MAO inhibition.
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DUse in LIFE-THREATENING emergencies when no safer drug availablePositive evidence of human fetal risk.
Non-renal clearance accounts for approximately 65of the total clearance of linezolidA small degree of non-linearity in clearance is observed with increasing doses of linezolidThis appears to be due to lower renal and non-renal clearance at higher linezolid concentrationsHoweverthe difference in clearance is small and is not reflected in the apparent elimination half-life.
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