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Do not use linezolid if you have taken an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidmethylene blue injectionphenelzinerasagilineselegilineand tranylcypromine.

Linezolid is not active against infections caused by Gram negative pathogensLinezolid should only be used in patients with complicated skin and soft tissue infections with known or possible co-infection with Gram negative organisms if there are no alternative treatment options availablesee section 4.4In these circumstances treatment against Gram negative organisms must be initiated concomitantly.

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